Abstract
The aim of the research: to substantiate the pathogenetic role of lipid metabolism disorders in the occurrence and course of pancreatitis in dogs and to establish the informativeness of its indicators for diagnosis and evaluation of treatment effectiveness based on clinical and laboratory research methods.
 Materials and methods. Used clinical, instrumental, laboratory methods, including morphological studies of blood, urine, biochemical studies of serum: determination of the lipid profile by the content of triacylglycerols, total cholesterol, lipoproteins cholesterol of very low – HDL, low – LDL and high density – VLDL, traditional tests and statistical methods.
 Results. It was found that the most significant changes are inherent in the metabolism of lipids and lipoproteins in the serum: significantly increased concentrations of cholesterol, triacylglycerols, LDL cholesterol and especially LDL cholesterol. The content of HDL cholesterol, on the contrary, in the acute course of pancreatitis is below normal. The content of triacylglycerols, LDL cholesterol and VLDL remains high. Total cholesterol is normalized, and the level of HDL is below normal.
 Conclusions. Serum lipidogram of dogs without clinical symptoms of pathology does not differ in composition from the results obtained by other researchers. For pancreatitis in dogs, the concentration of total cholesterol increases by 1.9 times, triacylglycerols – by 5.4 times, cholesterol VLDL – in 6.0 times and LDL cholesterol – 7.7 times. The content of HDL cholesterol, in contrast, in the acute course of pancreatitis is 1.5 times lower than in clinically healthy dogs. Treatment reduces the degree of hyperenzymemia by ALT and AST, but α-amylase activity is not normalized in dogs. Above normal levels of triacylglycerols, LDL cholesterol and VLDL, and HDL cholesterol remain low, despite treatment
Highlights
In domestic sources there are few publications on the violation of lipid metabolism in small domestic animals, in particular in dogs [1, 2]
There are no in-depth studies of the role of lipid metabolism disorders in the occurrence of pathology of the internal organs of dogs, in particular pancreatitis [5, 6]
The lack of comprehensive data on the indicators of lipid metabolism in normal and various forms of pathology in dogs necessitates a comprehensive study of lipid metabolism, which is an important point in the diagnosis of these disorders
Summary
In domestic sources there are few publications on the violation of lipid metabolism in small domestic animals, in particular in dogs [1, 2]. This issue is of particular interest as a problem of veterinary medicine, and in the general biological sense, because these animals in many cases are models of human pathology [3]. Etiological factors, in addition to disorders of lipid metabolism, can be emboli, ischemia of pancreatic tissues and others [6]
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