Influence of the degree of diffuse toxic goiter compensation on vitamin D blood level

Abstract

Patients with thyroid autoimmune diseases have lower blood level of vitamin D by comparison to a general population. However, there are few studies examining vitamin D status in patients with diffuse toxic goiter depending on the degree of disease compensation.A research aim was determination of vitamin D blood level in patients with diffuse toxic goiter, and also his possible influence on disease progression.Materials and methods. In cross-sectional study there were involved 57 women with diffuse toxic goiter of different degree of disease compensation. The first group was formed by women with diffuse toxic goiter in the state of protracted (over 6-9 months) thyrotoxicosis compensation (n=23). The second group was entered by 34 patients in the state of sub- and decompensation of diffuse toxic goiter. 25 practically healthy women without thyroid dysfunction and increase level of thyrotropin receptor antibodies were examined during the same period.Results and discussion. Vitamin D level (14.9±1.8 ng/ml) was significantly lower in patients with diffuse toxic goiter in sub- and decompensation state in comparison to the group of women with diffuse toxic goiter in the state of stabile thyrotoxicosis compensation (21.2±2.4 ng/ml) and control group (23.9±2.7 ng/ml). The results of correlation analysis revealed the presence in patients with diffuse toxic goiter in the sub- and decompensation thyrotoxicosis state significant negative connection between vitamin D range and level of thyrotropin receptor antibodies (r= –0.47; р<0.05).Conclusions. The vitamin D blood level depends on the degree of thyrotoxicosis compensation. Significant association between 25(OH)D range and level of thyrotropin receptor antibodies established in the group of patients with an uncompensated thyrotoxicosis.