Abstract
Immature male SHR and WKY rats were given demineralized water or solutions containing 1% NaCl, 5% sucrose or a solution containing both to drink over a period of 34 days. The consumption of each solution was greater than of water in both strains, and those containing sucrose were preferred over saline. Comparable volumes of sucrose and of sucrose-saline were consumed. The blood pressure of WKY was not influenced by any of the solutions, and none caused cardiac enlargement. Hypertension in SHR developed more rapidly and severely from the second week onward in those receiving sucrosesaline than in the other groups (which did not vary among themselves), and they displayed enhanced cardiomegaly. Heart rates tended to be faster in rats drinking sucrose solutions, but fell comparably among all groups as the animals grew. Neither sucrose nor saline alone increased blood pressure of SHR. The consumption of sucrose alone led to smaller adrenal and larger thymus glands.
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