Abstract
In frog atrial bundles it is possible under voltage clamp conditions to distinguish between a “phasic” component of mechanical response, depending on Ca++ influx, and a “slow” component, which does not directly depend on the presence of extracellular Ca++ (Vassort et Rougier, 1972). The present results suggest that the “slow” component can be abolished by substituting LiCl for NaCl. The hypothesis is advanced that a displacement of Ca++ by Na+ from some intracellular binding sites by a variation of membrane potential or [Na]i causes the “slow” phase of contraction.
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