Abstract
Background Migraine is sexually dimorphic and associated in 20% of patients with an aura of which cortical spreading depression (CSD) is the most likely cause. We have previously shown that CSD is suppressed by L-kynurenine (L-KYN), the precursor of kynurenic acid and that this effect depends on the stage of the estrous cycle in female rats [1].
Highlights
17b-estradiol levels do no significantly influence the suppressive effect of LKYN on cortical spreading depression (CSD)
Our findings show that both estrogens and, more surprisingly, progesterone increase CSD susceptibility
This might be relevant for the aggravation/appearance of migraine with aura during pregnancy or intake of a combined contraceptive pill
Summary
Migraine is sexually dimorphic and associated in 20% of patients with an aura of which cortical spreading depression (CSD) is the most likely cause. We have previously shown that CSD is suppressed by L-kynurenine (L-KYN), the precursor of kynurenic acid and that this effect depends on the stage of the estrous cycle in female rats [1]
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