Abstract
ABSTRACTOBJECTIVETo evaluate whether nitric oxide (NO) supplementa-tion is directly related to increased muscle power in response to strength exercise trainingMETHODSThe study included 36 individuals who underwent training for eight weeks (three times per week) with weights, who were randomly divided into two groups, both receiving the same training protocol, but one group used 3g of arginine, as a precursor of NO, and the other received placeboRESULTSThere was no significant difference between groups, only a significant difference for both groups between moments: before and after the training protocolCONCLUSIONOral administration of arginine asso-ciated with a training program did not increase the muscular power of individuals. Level of Evidence I, Study Type: Highquality randomized trial with statistically significant diffe-rence or no statistically significant difference but narrow confidence intervals.
Highlights
Nitric oxide (NO) is one of the smallest and simplest molecules ever biosynthesized.[1]
The production of NO in humans occurs when L-arginine is converted to L-citrulline, in a reaction catalyzed by the enzyme nitric oxide synthase (NOS).[7]
The objective of the present study is to investigate the effects of supplementation with NO in muscle power after performing an exercise protocol for muscle strengthening
Summary
Nitric oxide (NO) is one of the smallest and simplest molecules ever biosynthesized.[1]. NO has bactericidal properties.[3,4,5] NO is one of the most important mediators of intra-and extracellular processes.[6] Because it has a vasodilator function, NO acts in situations of muscle overload, stimulating the transition between the muscle fiber types.[7] The NO produced by vascular endothelial cells is an important regulator of the vascular function.[8] The production of NO in humans occurs when L-arginine is converted to L-citrulline, in a reaction catalyzed by the enzyme nitric oxide synthase (NOS).[7] The NO produced by endothelial cells plays an essential role in the relaxation of the blood vessel. Exercise training improves cardiovascular autonomic function and endothelial vasodilator systemically, promoting beneficial cardiac and vascular effects These benefits may be related to the increased production of NO.[12] According to Flakoll et al.,[13] supplementation of arginine (with beta-hydroxy-beta-methylbutirate) improves contractile force by increasing muscle protein synthesis. Supplementation for long periods, concomitant with a resistance-training program, may be associated with improvement
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