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Abstract
Objective To investigate the influence of nasal continues positive airway pressure (nCPAP) on retention of carbon dioxide(CO2) in newborns. Methods From June to December 2009, a total of 46 newborns who had nCPAP treatment for 72 hours in West China Second University Hospital, Sichuan University were included in nCPAP group. Meanwhile, another 20 cases of neonates with jaundice were selected as control group. The artery blood gas was detected by STEPHAN CPCP-B just before nCPAP treatment and at 30 min, 6 h, 12 h, 24 h, 36 h after nCPAP treatment in nCPAP group. The same method determined the artery blood gas in control group. The blood gas analysis results between nCPAP group before nCPAP treatment and control group, and between nCPAP group at different time slots and control group were analyzed by statistical methods. The procedure of this study was consistent with ethical standard which was established by the committee of investigation in human beings of West China Second University Hospital, Sichuan University. And it was approved by this committee. Guardians were informed of grouping and their written informed consent was obtained before clinical studies. There had no significance differences between two groups among gestational age at delivery, day age, and gender (P>0.05). Results There had significant difference between nCPAP group before nCPAP treatment and control group in pH value and partial pressure of oxygen in artery (PaO2)(P 0.05). The blood gas results of nCPAP group at different treatment time slots and control group showed that even using nCPAP in newborns with normal PaCO2 for 72 h, there were no signs of retention of CO2 (P>0.05). Conclusions Using nCPAP in newborn with normal PaCO2 for 72 h may not cause serous retention of CO2. Key words: nasal continues positive airway pressure; carbon dioxide retension; newborn
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