Abstract
ABSTRACTThe efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the liver. Immunohistochemical staining (proliferative activity, myofibroblast activation and sinusoidal capillarization) was evaluated to assess the efficacy of transplantation. It was found that, 2 months after stem cell transplantation, the severity of perisinusoidal fibrosis, inflammation of the liver and the number of myofibroblasts were reduced. Stem cell transplantation may be one of the new treatment modalities for cirrhotic liver.How to cite this article: Maksud AR, Gennadiyevich PA, Elkhan JR. Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver. Euroasian J Hepato-Gastroenterol 2014;4(2):83-86.
Highlights
Liver cirrhosis (LC) is a chronic progressive disease accompanied by fibrotic and regenerative restructuring of the parenchyma of the organ, hepatic and cell failure and gradual development of portal hypertension.[1]
The LC formation was determined by biochemical and morphological criteria
The structures of liver before and after inducing LC are shown in Figures 1A to D
Summary
Liver cirrhosis (LC) is a chronic progressive disease accompanied by fibrotic and regenerative restructuring of the parenchyma of the organ, hepatic and cell failure and gradual development of portal hypertension.[1] Despite the compromised function of the liver cells, hepatocytes are capable of regeneration Their mass deaths as well as their reduction under the influence of various damaging factors of regenerative potential of the liver lead to gradual change of the structure of the later by its replacement by fibrous tissues.[2,3] At present, there are many means of stimulation of the regenerative process of cirrhotic liver.[4] short-term outcome has usually been recorded. The main source of SC in the body is the bone marrow capable of generating precursor cells for a large number of body tissues.[6,7] In animal experiments and in the clinics, it has been shown that liver regeneration can be stimulated by autologous SC transplantation.[5,6] This study was conducted to assess the effectiveness of combined transplantation of mesenchymal SC in regeneration activity of the cirrhotic liver
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