Abstract
Objective: With apoptosis being critical for the development and homeostasis of placental tissues, it is possible to hypothesize that accelerated trophoblastic apoptosis during pregnancy may result in a partial loss of trophoblastic activity or trophoblastic cell mass, and ultimately may alter the second-trimester screening test parameters. Thus, this study was conducted to investigate the influence of maternal toxoplasmosis on second-trimester aneuploidy screening tests.Study Design: This retrospective study was conducted with 552 pregnant women admitted to our University Hospital. The demographic data such as maternal age and weight; and the main parameters of second-trimester aneuploidy screening test including maternal serum alpha-fetoprotein, unconjugated estriol (uE3) and human chorionic gonadotropin were analyzed with the comparison of their Toxoplasma immunoglobulin serology results.Results: The mean age of the pregnant women was 27.6 (17.0 - 43.0) years, and the mean maternal weight was estimated at 65.0 (40.0 - 120.0) kg. The pregnant women with positive Toxoplasma IgG antibody had a higher mean maternal age than those with negative Toxoplasma IgG antibody (p< 0.0001). No significant difference for the concentrations and MoM values of second-trimester screening test parameters in women with Toxoplasma IgM and IgG antibodies was observed (p> 0.05, for all).Conclusion: Although IgG-seropositivity of toxoplasmosis may lead to an accelerated trophoblastic apoptosis during pregnancy, there is no significant influence on the second-trimester screening test results. There was no data regarding the unaffected population whom used for calculation of MoM, if they
Highlights
IntroductionRegardless of their age or probable risk status, are offered screening tests to identify the risk for fetal aneuploidy including trisomy 21 and 18, and fetal open
IgG-seropositivity of toxoplasmosis may lead to an accelerated trophoblastic apoptosis during pregnancy, there is no significant influence on the second-trimester screening test results
There was no data regarding the unaffected population whom used for calculation of multiples of the medians (MoM), if they had toxoplasmosis in their life span
Summary
Regardless of their age or probable risk status, are offered screening tests to identify the risk for fetal aneuploidy including trisomy 21 and 18, and fetal open. Submitted for Publication: 17.09.2017 Accepted for Publication: 28.01.2018. Quick Response Code: Access this article online. How to cite this article: Gorkem U. Influence of Maternal Toxoplasmosis on the Second-Trimester Aneuploidy Screening Test.
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