Abstract
This study is done to evaluate the antioxidant effect of Lactoferrin (LF) on liver injury induced byDiazinon (DZN). Seventy five rats were divided into five groups, each group contains 15 rats;control (G1): (no treatments), Lactoferrin (G2): (LF, 100 mg/kg bw orally daily for 6 weeks),diazinon (G3): (DZN, 70 mg/kg bw orally, daily for 4 weeks), DZN +LF (G4): (DZN, 70 mg/kg bworally, daily for 4 weeks followed by LF, 100 mg/kg bw orally daily for 2 weeks, and (LF +DZN)group (G5): (LF, 100 mg/kg bw orally daily for seven weeks and DZN, 70 mg/kg bw for fourweeks only started at the second week of the experiment).Total leukocyte count (TLC) anddifferential leukocyte count (DLC) were checked in whole blood, cytokine IL-10, total proteins(TP)and protein electrophoresis were checked in serum. In comparison to control group, WBCs foundincreased significantly in DZN group(P<0.005) and IL-10, TP, albumin, and globulin were foundsignificantly decreased too. In comparison to DZN group, WBCs and IL-10, levels were foundsignificantly increased in (DZN+LF) group (P < 0.05), TP, albumin, and globulin levels were alsofound significantly increased (P < 0.05), WBCs found significantly decreased in (LF+DZN) groupand IL-10, TP, albumin, and globulin were found significantly increased too(P < 0.05) .
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