Abstract
Solid dispersions of ketoprofen with hydroxypropyl-β-cyclodextrin (HP-β-CyD) were prepared by coevaporation and freeze-drying. The objective was to improve the dissolution profile and reduce the ulcerogenic effect on gastric mucosa of this poorly soluble nonsteroidal anti-inflammatory drug. The dissolution of ketoprofen from these solid dispersions was studied in simulated gastric fluid, without pepsin, and was found to be significantly improved over that of ketoprofen powder alone. Reduction in ulcer-inducing effect was investigated in rats after oral administration of ketoprofen and its solid dispersions. A significant reduction in the ulcerogenic effect of ketoprofen was observed with the coevaporated dispersion. Dispersions of ketoprofen with HP-β-CyD dissolved faster thus significantly reducing the ulcerogenic effect of ketoprofen after oral administration in rats.
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