Abstract
BackgroundCoronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. Low High-density lipoprotein cholesterol (HDL-C) level is a strong risk factor for coronary artery disease (CAD) and is associated with poor cardiovascular outcome. It was recently reported to be associated with poor coronary collateral development in Turkish population. Hence, we investigated the influence of HDL-C on coronary collateral formation in Chinese population.MethodsWe evaluated 970 consecutive patients undergoing coronary angiography, and 501 patients with significant coronary artery disease (SCAD) were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patient groups as those with poor or good collaterals.ResultsThe patients with poor collaterals had fewer diseased vessels (1.97 ± 0.84 vs 2.47 ± 0.68, p < 0.001) and lower diffuse score (2.65 ± 1.63 vs 3.76 ± 1.78, p < 0.001). There was no significant difference in HDL-C and other variables between good and poor collaterals. Multivariate analysis showed only number of diseased vessels (odd ratio 0.411, p < 0.001) was a significant predictor of poor collateral development.ConclusionsThe extent of CAD severity but not HDL-C level was the most powerful predictor of coronary collateral formation in our Chinese population with SCAD.
Highlights
Coronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events
We wanted to investigate the influence of High-density lipoprotein cholesterol (HDL-C) on coronary collateral formation in a Chinese population with significant coronary artery disease (CAD) (SCAD)
CAD severity scoring by coronary angiography We evaluated the extent of coronary artery atherosclerosis by a “diffuse score” (DS) developed by Negri et al
Summary
Coronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. Low High-density lipoprotein cholesterol (HDL-C) level is a strong risk factor for coronary artery disease (CAD) and is associated with poor cardiovascular outcome. It was recently reported to be associated with poor coronary collateral development in Turkish population. Low high-density lipoprotein cholesterol (HDL-C) is an independent risk factor for coronary artery disease (CAD) and is associated with increased cardiovascular event [1,2,3]. HDL-C was recently reported to be associated with poor coronary collateral development in a Turkish population [10]. We wanted to investigate the influence of HDL-C on coronary collateral formation in a Chinese population with significant CAD (SCAD)
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