Abstract
Plasma thrombin-antithrombin heparin cofactor is generally attributed to the activity of antithrombin III (AT) (1,2). Recently, a new plasma inhibitor, heparin cofactor II, has been purifiedand characterized (3,4). Because of the presence of both thrombin inhibitors in plasma, the assay of plasma AT by heparin cofactor activity includes the effect of HCII. Furthermore, Friberger et al (5) have reported that the second heparin cofactor inhibits more pronouncedly human thrombin than bovine thrombin while comparing different assays of human AT. A reinvestigation of the assay of plasma heparin cofactor requires plasma depleted of either AT or HCII. In this report, to show quantitatively the contribution of HCII, the heparin cofactor activity is determined in plasmabefore and after immunoadsorption by using human or bovine thrombin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
