Abstract
BackgroundBioactivities of plant-based compounds had been shown to be influenced by properties of the extracting solvents. This study investigated the influence of ethanolic extract of Xylopia aethiopica (Dunal) A. Rich on the haematological and biochemical parameters in apparently healthy Wistar Rats using solvent partitioning.MethodsThe procedures involved partitioning of ethanolic extract of X. aethiopica (Dunal) A. Rich into n-hexane and aqueous fractions, chosen based on their differences in polarities and dielectric constants. The samples were administered at doses of 100 mg/kg body weight and 200 mg/kg body weight orally once per day for a period of fourteen (14) days to apparently healthy male Wistar rats that had been randomly selected into seven (7) groups. Haematological parameters and plasma biochemical indices were determined using standard protocols after the rats were sacrificed on the 15th day.ResultsThe results showed that the levels of haematocrit and related parameters in all the groups that received the extract when compared to the control increased significantly (p < 0.05). Additionally, no detrimental effect was observed on the levels of endogenous antioxidants, liver and kidney function indices in the rats compared to the control.ConclusionIn summary, on the basis of these findings, this study suggests that the extracts may be capable to alleviate the pathologies that are associated with haematological disorders through improvement of endogenous antioxidant status. The study proposes further evaluation on the molecular mechanism of bioactive components of X. aethiopica (Dunal) A. Rich as agents that can prevents anaemia.
Highlights
Bioactivities of plant-based compounds had been shown to be influenced by properties of the extracting solvents
The level of white blood cell (WBC) was significantly higher in the HPE100 mg/kg, HPE200 mg/kg, APE 100 mg/kg and ECE100 mg/kg; the mean percentage neutrophils were increased compared to the control in HPE200mg/kg, APE 200 mg/kg, ECE100mg/kg, and ECE200mg/kg groups while the opposite was true for percentage lymphocytes
The platelet levels were lowered in the groups that received ECE and APE at 200 mg/kg body weight compared to the control
Summary
Bioactivities of plant-based compounds had been shown to be influenced by properties of the extracting solvents. Major defence mechanisms against oxidative stress include enzymatic (catalase (CAT), glutathione peoroxidase (GPx), Plant based natural products and food containing antioxidant nutrients have been established to lower the (2019) 5:9 incidence of oxidative stress-related pathologies [8] These plant materials have been effective sources of traditional medicines against many ailments since ancient times. These medicinal plants contain various biologically active compounds which are believed to play essential roles in the amelioration of diseases that are associated with oxidative stress by reducing the concentrations free radicals in the system. The present study was aimed at investigating the influence of extract partitioning based on polarities on haematological and biochemical parameters in healthy Wistar rats
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