Abstract
In this paper, ZnO and Co2+/Mg2+-doped ZnO thin films on TiAlV alloy substrates were obtained. The films were deposited by spin coating of sol-gel precursor solutions and thermally treated at 600 °C for 2 h, in air and slow cooled. The doping ions concentration was 1.0 mol%. The study’s aim was to obtain implantable metallic materials with improved biocompatibility and antibacterial qualities. The characteristics of the thin films were assessed from the point of view of microstructure, morphology, wetting properties, antibacterial activity and biological response in the presence of amniotic fluid stem cells (AFSC). The results proved that all deposited samples were nanostructured, suggesting a very good antibacterial effect and proving to be suitable supports for cellular adhesion and proliferation. All properties also depended on the doping ion nature.
Highlights
Microbial infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi, and are a major cause of morbidity and mortality [1,2]
Several types of strains, such as Escherichia coli, Klebsiella pneumoniae, Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus have been recognized as the pathogens that have developed the highest resistance to conventional remedies [3]
The doping of ZnO with Co2+/Mg2+modifies the ratio between the intensities of principal peaks ((100), (002) and (101)), and this can be observed in the detail of X-ray diffraction (XRD) patterns between 38–42◦
Summary
Microbial infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi, and are a major cause of morbidity and mortality [1,2]. There has been an increase in the number of pathogens that confer multiple resistance to drugs and to various antibacterial agents. An antibacterial agent used against infectious diseases could be ZnO that has been extensively studied by many researchers owing to its potential applications in for example gas sensors, photo-catalysts, dye-sensitized solar cells, antibacterial applications, water purification, textiles, food packaging, pharmaceutical and biological applications. Zinc oxide nanoparticles are a semiconductor material with a wide band gap (~3.37 eV), large exciton-binding energy (~60 meV) and chemical stability [7,8,9]. The mechanism of antibacterial action of the material is that the production of reactive oxygen species on the surface of these ZnO nanoparticles in light causes oxidative stress in bacterial cells and eventually leads to the death of the cells. Reactive oxygen species contain the most reactive hydroxyl radical, a less toxic superoxide anion radical, and hydrogen peroxide with a weaker oxidizer [10]
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