Abstract
[Ga]GaCl3 and AMD-3100 for 2 h at 50 °C (radiochemical purity: N95% ITLC, N99% HPLC, specific activity: 1800–2000 TBq/mmol) in acetate buffer. Stability of the complex was checked in presence of human serum (37 °C) and in final formulation for 4 days. The biodistribution of the labeled compound in vital organs of wild-type Sprague–Dawley rats were determined and compared with that of free Ga cation up to 48 h. Considering spleen as the target organ, the best target:non target ratios were obtained 48 h post injection (spleen:blood ratio; 14.5 and spleen: muscle ratio; 88.4). Initial SPECT images and biodistribution results in wild type rats matched each other and demonstrate rapid wash out of the tracer from urinal tract. SPECT images in human breast carcinoma-bearing mice demonstrated detectable tumor uptake in 48 h post injection.
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