Abstract
In vitro 10 −4 M chlorpromazine did not influence decarboxylation of 5-hydroxytryptophan (5HTP) and 3 : 4-dihydroxyphenylalanine (dopa) in supernatant of rat brain and kidney. 10 −3M chlorpromazine only inhibited dopa decarboxylation in brain supernatant to which no pyridoxal-5′-phosphat (py-5-p) had been added. Pretreatment of intact rats with high doses of chlorpromazine had no significant effect on decarboxylation of dopa or 5HTP in total homogenates or supernatant of brain. In supernatant of kidney of rats pretreated with chlorpromazine there was, however, a 30–70 per cent rise in decarboxylation of dopa and 5HTP, provided that no py-5-p was added to the incubation medium. The results are discussed with regard to the effects of chlorpromazine on the metabolism of py-5-p and aromatic monoamines.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
