INFLAMMATORY PROCESSES AND POTENTIALLY PATHOGENIC MICROFLORA AT POLYCYSTIC OVARY SYNDROME UNDER CONDITIONS OF INCREASED EXPOSURE BY MANGANESE AND NICKEL

Abstract

Objective. Investigation of the frequency of inflammatory processes and indices of potentially pathogenic microflora in women with polycystic ovary syndrome (PCOS) under conditions of increased exposure of manganese and nickel.Material and methods. Two groups of women were selected. The first control group consisted of 57 healthy women of reproductive age. The second group is 64 women with PCOS. Both groups did not differ in body weight. The analysis of the frequency of inflammatory processes was carried out according to the microscopic characteristics of vagina’s microbiocenosis. The presence of pathogenic infections (Neisseria gonorrhoeae, Chlamydiales, Trichomoniasis, Herpes 1 and 2 types, Cytomegalovirus, M. genitalium) was excluded using the Real-Time PCR method and quantitative evaluation of the Gardnerella vaginalis + Prevotella bivia + Porphyromonas spp., Candida spp., Ureaplasma spp ., Mycoplasma hominis and Lactobacillus spp.was conducted. The validity of the results was evaluated using the criteria of U-Mann-Whitney and t-Student.Results. In the absence of sexual pathogenic infections in women with PCOS, signs of inflammatory processes of the vagina are much more common. In control, pathological samples were found in 10.52%, in women with PCOS - 84.38% (P = 0.000). Inflammatory processes in women with PCOS are accompanied by a decrease in the number of lactobacillus and an increase in the number of obligate anaerobic bacterias and Mycoplasms. In women with PCOS, fungi of the genus Candida are more often detected, but no increase in quantitative indicators was found.Conclusion. Inflammatory processes with PCOS are accompanied by violations of vaginal biocenosis. The elevated exposure level of manganese and nickel can be considered as a cofactor of microflora disturbances in the body.