Abstract

Inflammatory myofibroblastic tumor is an uncommon soft tissue neoplasm of uncertain biologic behavior, and rarely reported in the stomach. An eighteen-year-old male presented with a mass in the epigastrium of three-month duration. Clinical and radiological examination suggested a gastrointestinal stromal tumor or a leiomyoma in the lesser curvature of the stomach. On the basis of histomorphological features and immunohistochemical analysis the diagnosis of inflammatory myofibroblastic tumor in the lesser curvature of the stomach was made. Inflammatory myofibroblastic tumor should be considered in the differential diagnosis of soft tissue tumors of the stomach.

Highlights

  • Inflammatory myofibroblastic tumors (IMTs) are distinctive mesenchymal neoplasms of intermediate biologic potential that are composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes and eosinophils [1]

  • Inflammatory myofibroblastic tumor (IMT) has been named as inflammatory pseudotumor, inflammatory myofibroblastic proliferation, plasma cell granuloma or inflammatory myofibroblastoma [4]. It is classified under intermediate neoplasms in World Health Organization, Histological Typing of Soft Tissue Tumors [8]

  • About 34 gastric IMT cases reported in the English literature

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Summary

INTRODUCTION

Inflammatory myofibroblastic tumors (IMTs) are distinctive mesenchymal neoplasms of intermediate biologic potential that are composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes and eosinophils [1]. The first IMT was reported in the lungs, in 1937 [2]. Common extrapulmonary sites are mesentery, omentum, liver, urinary bladder and retroperitoneum. The tumor shows tendency for local invasion, recurrence, multicentricity and metastasis [3]. IMTs are rarely reported in the stomach [4,5,6,7]. They are usually misdiagnosed clinically and radiologically and pose a diagnostic dilemma even on histopathological examination, which is why we presented this case

CASE REPORT
Turkish Journal of Pathology
Findings
DISCUSSION

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