Abstract
Inflammation, induced by turpentine (0.1 ml i.m.), protected against carbon tetrachloride (CCl 4-induced hepatotoxicity based on serum activities of sorbitol dehydrogenase. Inflammation was confirmed by elevated serum ceruloplasmin activities, and was associated with high hepatic levels of metallothionein, a zinc protein proposed to protect against CCl 4-induced injury. Inflammation suppressed cytochrome P-450 activities, but this was not associated with protection against CCl 4-promoted liver microsomal injury as assessed by glucose-6-phosphatase activity loss. Thus, protection against plasma membrane injury did not result primarily from depressed microsomal activation of CCl 4. Each effect of inflammation reported here resembled effects of zinc injections. This similarity strengthens the hypothesis that metallothionein protects against CCl 4-induced hepatic plasma membrane injury.
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