Abstract
BackgroundAlpha-synuclein and inflammatory pathology are evident in Parkinson's disease (PD) but, their link to disease pathogenesis needs further elucidation. ObjectivesTo explore α-synuclein-mediated inflammation in the serum of PD patients and its link with disease severity. MethodsSerum levels of IL-1β, NLRP3, total and phosphorylated α-synuclein were compared. ResultsIL-1β, NLRP3 levels were significantly increased in PD. We also observed a linear correlation of NLRP3 with α-synuclein. Phosphorylated α-synuclein levels were significantly elevated in later stages of PD. ConclusionsThe α-synuclein-NLRP3 mediated inflammation may underline the pathophysiology of PD and might serve as a novel therapeutic target in PD.
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