Abstract
AbstractMany cardiac diseases have an inflammatory component by which the initial injury is amplified by an overzealous inflammatory response leading to further tissue injury, and impairing the recovery of cardiac function. The formation of the inflammasome in the heart represents a newly identified amplifying step in the pathogenesis and pathophysiology of different cardiovascular conditions. Initial experimental animal studies and small pilot clinical studies suggest that targeting the inflammasome in its different components interrupts this amplification process and promotes more favorable healing. The inflammasome represents therefore a new villain in the fight against heart disease.
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