Abstract
An increased percentage of the elderly subjects in pattern of contemporary society, along with other causes and risk factors, is accompanied by rise in the incidence of glaucoma. By 2020, according to international studies it is expected that prevalence of glaucoma patients in the world would increase up to 80 million subjects. Among the elderly, glaucoma is a common pathology, which development is associated with local disturbances in interleukin profile. However, the features of the latter in patients with primary closed-angle glaucoma in the elderly were poorly examined. Studies of local interleukin status were conducted mainly in patients with suspected or initial manifestations of primary open-angle glaucoma. The features of lacrimal fluid interleukin shift in a target group of elderly patients suffering from stage II primary closed-angle glaucoma virtually gained no attention. In addition, a limited range of local interleukins in patients with such pathology in previous studies was examined. In addition, informativity of lacrimal fluid interleukins in elderly glaucoma patients was not assessed too based on objective methods. The aim of the current study was to outline features and informativity of local interleukin profile indicators in 58 elderly patients with primary closed-angle glaucoma stage II, aged 60—74 years (main group) and 27 age-matched elderly subjects lacking such pathology. The level of interleukins in the lacrimal fluid was determined with the enzyme immunoassay “Multiscan” analyzer (Finland) by using sandwich ELISA (RD Diagnostic Inc., USA). Informativity of measuring various interleukins was calculated according to the generally accepted formula. It was found that local interleukin profile in elderly patients with primary closed-angle glaucoma was mainly featured with increased amount of IL-2, IL-17, IL-8, but decreased IL-10. Hence, such local interleukins displayed peak informativity. The data obtained should be used in the diagnostics and treatment of such pathology, as well as of applied importance to unveil novel mechanisms behind development, diagnostics and corroboration for selective immuno-tropic therapy of primary closed-angle glaucoma.
Highlights
В сельской местности [19]
The data obtained should be used in the diagnostics and treatment of such pathology, as well as of applied importance to unveil novel mechanisms behind development, diagnostics and corroboration for selective immunotropic therapy of primary closed-angle glaucoma
Что у пациентов пожилого возраста с первичной закрытоугольной глаукомой развитие патологического процесса протекает преимущественно на фоне местной гиперпродукции IL-17 и IL-2, тогда как у лиц среднего возраста с аналогичным заболеванием и стадией, наблюдавшихся Маркеловой Е.В., формирование патологии сопровождалось гиперпродукцией в слезной жидкости только IL-2
Summary
Однако особенности последнего у больных с первичной закрытоугольной глаукомой в пожилом возрасте практически не изучены. Особенности сдвигов интерлейкинов в слезной жидкости в целенаправленной группе пожилых больных, страдающих первичной закрытоугольной глаукомой II стадии, практически не анализировались. Цель настоящей работы — выявление особенностей и информативности показателей локального интерлейкинового профиля у пожилых больных с первичной закрытоугольной глаукомой. Обследованы 58 больных с первичной закрытоугольной глаукомой II стадии в возрасте 60–74 года (основная группа) и 27 пожилых людей аналогичного возраста без данной патологии. Особенностями местного интерлейкинового профиля больных первичной закрытоугольной глаукомой пожилого возраста являются повышенный уровень в слезной жидкости противовоспалительных IL-2, IL-17, IL-8 и снижение продукции противовоспалительных IL-10. Библиографическое описание: Чухраев А.М., Агарков Н.М., Коняев Д.А., Попова Е.В., Яблоков М.М., Кулабухов А.С. Информативность интерлейкинов слезной жидкости в диагностике и развитии закрытоугольной глаукомы в пожилом возрасте // Инфекция и иммунитет. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation b South-West State University, Kursk, Russian Federation c Belgorod State National Research University, Belgorod, Russian Federation d Fyodorov Eye Microsurgery Federal State Institution, Tambov, Russian Federation е Kursk State Medical University, Kursk, Russian Federation
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