Abstract
The clinical link among diabetes, obesity, and thyroid dysfunction is of interest. Hence, medical records of 601 patients with diabetes, obesity, and thyroid dysfunctions at the Abha Specialist Center and Military Diabetic Endocrine Center we used in this analysis. Approximately 28% of diabetic patients had thyroid dysfunction, and 12.4% were vitamin D deficient. The patients with thyroid dysfunction had significantly elevated triglyceride levels compared to the patients without thyroid dysfunction (173.6 vs. 128. p=0.009). Vitamin D deficient obese patients were significantly younger (33.99±10.69 vs. 43.68±14.42; p<0.001) and had significantly lower levels of HbA1c (5.73±1.16 vs. 6.83±2.08; p=0.014) and lower systolic BP (120.26±11.75 vs. 124.58±13.63; p=0.049) than non-vitamin D deficient obese patients. Vitamin D deficient thyroid patients had significantly lower diastolic BP (71.4±9.9 vs. 74.9±9.7; p=0.040) and higher HbA1c (8.7±3.6 vs. 6.4±1.7; p=0.003) in comparison to non-vitamin D deficient thyroid patients. Hence, analysis of metabolic disorders in these patients will help combat complications in these cases.
Highlights
Diabetes mellitus, a complex metabolic disease, is caused by impaired insulin secretion and results in chronic hyperglycemia [1]
A study from Saudi Arabia reported a high incidence of vitamin D deficiency in obese children aged 1-10 years (52.1%) [13]
32% of diabetic patients were elderly (>60 years), while only 5.5% of obese patients and 11.4% of patients with thyroid dysfunction belong to this age group (>60 years)
Summary
A complex metabolic disease, is caused by impaired insulin secretion and results in chronic hyperglycemia [1]. Obesity is suggested as a cause of a similar increased incidence of type 1 diabetes [5]. Thyroid disorders are a leading health concern in these patients.[8]In 1927, Coller and Huggins investigated that hyperthyroidism was associated with worsening of diabetes. A study from Saudi Arabia reported a 16% prevalence of thyroid dysfunction among diabetic patients [12]. A study from Saudi Arabia reported a high incidence of vitamin D deficiency in obese children aged 1-10 years (52.1%) [13]. Another study suggested severe vitamin D deficiency among 27.4% of Saudi children with obesity [14]. It is of interest to record the clinical link among diabetes, obesity, and thyroid dysfunction in Saudi Arabia
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