Abstract
Results of corticotropin treatment of 33 patients with infantile spasms are reported from the Instituto Clinica Pediatrica, Universita di Siena, Italy.
Highlights
Drop in IQ was halted; (4) the residual homonymous hemianopia was not a major handicap; and (5) one patient developed hemosiderosis of the postoperative cavity and died 11 years after operation
Post-operatively, (1) habitual epilepsy was interrupted with complete freedom in 11 (65%); (2) behavior improved, sometimes dramatically; (3)
The authors make the following recommendations: (1) establish that the lesion is unilateral and medication has been tried fully, (2) weigh dangers of status epilepticus, escalating behavior disorder, and deterioration of IQ when operation is delayed compared to benefits and low risks of early surgery; (3) use improved operative techniques with dissection of cortex in single piece (Falconer and Rushworth) and reconstruction and closure of cavity (Adams), and (4) regular follow-up with CT scans
Summary
Drop in IQ was halted; (4) the residual homonymous hemianopia was not a major handicap; and (5) one patient developed hemosiderosis of the postoperative cavity and died 11 years after operation. The median age at operation was 11^ yrs (7-17 yrs). Post-operatively, (1) habitual epilepsy was interrupted with complete freedom in 11 (65%); (2) behavior improved, sometimes dramatically; (3)
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