Abstract
Parkinson's Disease is a neurodegenerative disorder with a great global impact and, despite recent advances, it still needs improvement in the methods for assessing motor alterations. This study aimed at evaluating a system (hardware and software) capable of accurately quantifying tremor in patients with Parkinson's disease that underwent pallidotomy. The Mean Absolute Value (MAV) of the involuntary activity of three patients that underwent pallidotomy surgery - in the pre and postoperative scenarios- was evaluated. The Mean Absolute Value of involuntary activity obtained through the suggested device (TREMSEN) showed a good correlation with the clinical findings, as well as with the findings already described in previous studies. The present study showed that MAV alterations were always positively related to tremor, or negatively related to bradykinesia and rigidity, or possibly both. A tendency towards greater tremor influence on the MAV than bradykinesia and rigidity was also observed. The positive correlation among the values measured by the TREMSEN device and the patients´ clinical result opens doors for the future application of technology, such as accurate and objective assessment of motor disorders, continuous monitoring and remote monitoring.
Highlights
Parkinson's Disease (PD) is the fastest growing neurodegenerative disorder in the recent years in terms of prevalence, disability and number of deaths. (Ray Dorsey et al, 2018) Its prevalence is 1-2 individuals per 1000 at all ages and affects 1% of the population over 60 years, being the second most common neurodegenerative disease. (Tysnes & Storstein, 2017)(Ascherio & Schwarzschild, 2016; Elbaz et al, 2016)The current gold standard used to assess PD symptoms is the use of scales and questionnaires based on observation and clinical tests, either to quantify the severity of the disease or to assess the therapeutic response
This study aims at evaluating the motor signs of patients with Parkinson's Disease who underwent pallidotomy with the TREMSEN device, as well as the description of the results obtained and their comparison with the neurological exam using the MDS-UPDRS-III scale.Use the paragraph as a template (TNR font 10 – justified – space 1,5)
We conduced a prospective observational diagnostic pilot study to compare the results obtained with the proposed method (TREMSEN) with the established gold standard method (MDS-UPDRS-III) for the assessment of motor disorders in Parkinson's Disease
Summary
Parkinson's Disease (PD) is the fastest growing neurodegenerative disorder in the recent years in terms of prevalence, disability and number of deaths. (Ray Dorsey et al, 2018) Its prevalence is 1-2 individuals per 1000 at all ages and affects 1% of the population over 60 years, being the second most common neurodegenerative disease. (Tysnes & Storstein, 2017)(Ascherio & Schwarzschild, 2016; Elbaz et al, 2016)The current gold standard used to assess PD symptoms is the use of scales and questionnaires based on observation and clinical tests, either to quantify the severity of the disease or to assess the therapeutic response. Parkinson's Disease (PD) is the fastest growing neurodegenerative disorder in the recent years in terms of prevalence, disability and number of deaths. (Ray Dorsey et al, 2018) Its prevalence is 1-2 individuals per 1000 at all ages and affects 1% of the population over 60 years, being the second most common neurodegenerative disease. (Tysnes & Storstein, 2017). The current gold standard used to assess PD symptoms is the use of scales and questionnaires based on observation and clinical tests, either to quantify the severity of the disease or to assess the therapeutic response. The most used scale is the Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS), which is divided into four parts, the third one (MDS-UPDRS-III) being responsible for the motor assessment. The most used scale is the Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS), which is divided into four parts, the third one (MDS-UPDRS-III) being responsible for the motor assessment. (Goetz et al, 2008) (Monje et al, 2019)
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