Abstract
The inducing effects of musk xylene, a non-mutagenic carcinogen, on hepatic glutathione S-transferase (GST) in mice were investigated. Musk xylene posessed a potency of inducing all isozymes of mouse GSTs, whereas the effects were different between male and female mice. Induction of both GST MI (α class) and GST MII (π class) by musk xylene was observed only ip female. GST MIII (μ class) was induced up to about 5-fold by musk xylene in both sexes. The induction of MIII was higher than those of the other isozymes. There were strain differences in the induction of MII and MIII by musk xylene in female mice. The induction observed in C57BL/6N female mice was higher than that in DBA/2N female mice. These results indicate that musk xylene possesses multifunctional effects on GST induction in male and female mice.
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