Abstract
The effect of partial hepatectomy (67–75 per cent excised) on aryl hydrocarbon (benzo[a]pyrene) hydroxylase and 2-acetylaminofluorene N-hydroxylase activities in genetically responsive C57BL/6N and nonresponsive DBA/2N inbred strains of mice was studied. Basal aryl hydrocarbon hydroxylase activity in C57BL/6N mice is reduced by 70 per cent within 12 hr but returns to control values between 36 and 48 hr after the operation and remains at that level thereafter. Similar, but less pronounced, changes are observed in the DBA/2N mouse. Treatment with 3-methylcholanthrene (80 mg kg −1 intraperitoneally) 1 hr after partial hepatectomy induces aryl hydrocarbon hydroxylase in C57BL/6N mice, by 48 hr, to the same extent as in mice with intact livers. In DBA/2N mice, even after partial hepatectomy, treatment with 3-methylcholanthrene has no effect on aryl hydrocarbon hydroxylase activity. The effect of partial hepatectomy and 3-methylcholanthrene treatment on 2-acetylaminofluorene N-hydroxylase activity in both strains of mice is similar to that observed on aryl hydrocarbon hydroxylase activity.
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