Abstract
AIM: Recent studies have shown that Helicobacter pylori (Hp) infection is etiologically associated with gastric cancer. However, the role of Hp in carcinogenesis is unknown. Hp infection leads to a sustained production of the reactive nitrogen species which cause DNA damage. In this study, we examined the expression of inducible nitric oxide synthase (iNOS) and nitrotyrosine in human non-cancerous gastric mucosa. MATERIALS and METHODS: A total of 93 archival gastric biopsy specimens were used. The 34 biopsy specimens from gastric cancer patients were obtained two years or more before diagnosis of gastric cancer (Group A). The other 59 specimens were from the patients who had no evidence of gastric cancer during long term follow-up (Group B). These two groups were age and gender matched. Immunohistochemical analysis was performed to examine the expression of iNOS and nitrotyrosine. RESULTS:
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