Abstract
Twenty-four or 12% of 204 hamsters fed an iodine deficient diet of rice and carrots developed thyroid cancer with metastases to lymph nodes or lungs. An additional 57 or 28% had probable cancer and 121 or 59% had thyroid hyperplasia. Histologically, the cancers were follicular adenocarcinomas. For the most part, they were so well differentiated as to preclude a definite diagnosis of cancer in the absence of metastases. The well differentiated, metastatic cancers are comparable to the “metastasizing struma” of man. The neoplastic changes in the thyroid gland were diffuse, suggesting TSH stimulation. The findings were confirmed in a second experiment using hamsters from a different source. However, metastatic thyroid cancer was found only in females of this experiment. This could be a result of fortuitous selection or a manifestation of genetic differences. In other experiments, spontaneous thyroid cancer was found in 8 or 1.5% of 523 hamsters surviving 181 days or longer on a diet of Purina Laboratory Chow...
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