Indispensable and replaceable amino acids in the blood serum and their relationship with macro- and microelements in the newborns of Fe-deficient anemic mothers (in conditions of an industrial city)

Abstract

Anemia of the newborn is undoubtedly an actual problem in pediatrics. The imbalance between amino acids and biologically active macro- and microelements participating in hematopoiesis and Fe metabolism play an important role in its pathogenesis. Therefore knowledge of amino acid metabolism in the newborn helps to gain insight into pathogenetic mechanisms and to choose the right therapy. A complex inspection of 169 newborns of 18–34-year-old women was done. The control group consisted of 42 newborns of women with normal pregnancy and parturition. The case group consisted of 127 newborns of women with Fe-deficit anemia. Unquestionably one of the factors of Fe-deficit anemia of women aggravates the gestation period, delivery and after-birth period, and has an injurious effect on the newborn. Changes in the trace element and free amino acid metabolism were interconnected in the “mother–newborn” system as evidenced from correlations between the levels of some amino acids, trace element metabolism and erythropoiesis. The pathogenetic importance of the disturbance of the trace element and amino acid metabolism dictates the choice of the correct therapy of Fe-deficit anemia of pregnant women. The experience and results of our investigations support the necessity of preventive estimation of the content of macro- and microelements and amino acids in the blood serum of newborn to correct metabolic disturbances.