Abstract
Simple, accurate and sensitive indirect spectrophotometric method for assay of diclofenac (Di) and Isoxsuprine (IS) in pure and pharmaceutical formulation has been developed. The method is based on oxidation of (Di) and (IS) by N-bromosuccinimide in acidic medium. The excess of oxidant is determine by reaction with malachite green dye and the absorbance is measured at 615nm. Under the optimized experimental conditions, Beer's law is obeyed in concentration range 0.5-18 , 1-18 µg/ml with molar absorptivity 5.1×104 and 4.6×104 L.mol-1.cm-1 for (Di) and (IS) respectively. The limits of detection (LOD) 0.0314, 0.038 and quantification are 0.0104 , 0.126 µg/ml. with the accuracy (average recovery) 100.80%, 101.20% for above drugs respectively and the precision (RSD) less than 1.5% for both drugs. The proposed method is applied successfully for assay of pharmaceutical formulations.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
