Abstract
Background: Authors and colleagues have undertaken clinical research on Carbohydrate (CR) and Low Carbohydrate Diet (LCD) for years. We have proposed new evaluation method of insulinogenic index-carbohydrate 70g (IGI-carbo70). In similar way, C-peptide index for Carbohydrate-70 (CPI-Carbo70) is proposed in this report. Subjects and methods: The subjects were 37 patients with Type 2 diabetes mellitus (T2DM) and admitted for further evaluation and treatment. CR diet was provided on day 1 and 2, including 60% carbohydrates, 25% lipids and 15% protein with 1400 kcal/day. On day 2, breakfast with 70g of carbohydrate was provided, and glucose and C-peptide values were measured at 0 and 30 minutes. Results: Average HbA1c was 8.1 %, and Morbus (M) value was 70.5 in median. Glucose and C-peptide on 0--30min significantly increased as 163--195 mg/dL, 1.1--1.5μU/mL, respectively. CPI-Carbo70 was 1.94 in average and 1.54 in median. There were significant correlations between increments of glucose and C-peptide, and between HbA1c and CPI-Carbo70. Discussion and conclusion: CPI-Carbo70 was investigated and proposed. It may be useful for evaluating the function of the pancreas. This research would give the fundamental data for this field, and further research development will be expected in the future.
Highlights
Diabetes has been a medical and social serious problem in the world
Glucose and C-peptide on 0--30min significantly increased as 163--195 mg/dL, 1.1--1.5μU/mL, respectively
This research would give the fundamental data for this field, and further research development will be expected in the future
Summary
Diabetes has been a medical and social serious problem in the world. Its number of diabetic patients is increasing and about 425 million, including 30 million in United States, 73 million in India and 110 million in China [1]. There have been various comments concerning diabetes guidelines. The American College of Physicians (ACP) presented official comments concerning diabetes [3]. Rather surprising statement was found that clinicians should set the management goal for HbA1c in most type 2 diabetic patients to be 7% or more and less than 8%. It has made a paradigm change for diabetic treatment. We have proposed new evaluation method of insulinogenic index-carbohydrate 70g (IGI-carbo). C-peptide index for Carbohydrate-70 (CPI-Carbo70) is proposed in this report
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