Abstract
An efficient and green synthesis of 1-amidoalkyl-2-naphthols via one-pot three-component con- densation of aromatic aldehydes, acetamide and 2-naphthol in the presence of catalytic amounts of glyc- erosulfonic acid in glycerol as a green solvent was elaborated. Also a simple method for the one-pot three- component synthesis of 2,3-dihydroquinazoline-4(1H)-ones using of isatoic anhydride, aldehydes and ammonium acetate in the presence of glycerol as a green catalyst and solvent was described. In this light we introduced the brilliant and valuable role of glycerol in the synthesis of 2,3-dihydroquinazoline-4(1H)- ones and 1-amidoalkyl-2-naphthols.
Highlights
Multicomponent reactions (MCRs), have elicited increasing interest since they have been performed without the need to isolate any intermediate during their processes, this reduces time and saves both energy and raw materials.[1]
Glycerol is a nontoxic, biodegradable and nonflammable solvent for which no special handling precautions or storage is required. It is a by-product of the production of biodiesel via trans-esterification and co-product of the vegetable oil industry.[28]. In this light we introduced the important role of glycerol in the synthesis of 2,3-dihydroquinazoline-4(1H)-ones and 1-amidoalkyl2-naphthols
In we investigated glycerol as green media with dual role for the one-pot three-component reaction of isatoic anhydride, aromatic aldehydes, and ammonium acetate for the synthesis of 2,3-dihydroquinazoline derivatives
Summary
Multicomponent reactions (MCRs), have elicited increasing interest since they have been performed without the need to isolate any intermediate during their processes, this reduces time and saves both energy and raw materials.[1] This reactions play as an important tool for building diverse and complex organic molecules in a tandem manner They are suitable for library synthesis to meet the demands for high-throughput screening in the pharmaceutention from both academic and industrial researchers.[2] Two of these MCRs are the synthesis of 1-amidoalkyl-2-naphthols and 2,3-dihydroquinazoline-4(1H)-ones. Various procedures have been developed for preparing this important class of compounds.[19] Other methods including synthesis of 2,3dihydroquinazoline 4(1H)-ones via one-pot threecomponent reaction catalyzed by L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate (supported on silica gel),[20] Cu-CNTs,[21] copper-catalyzed,[22] Ce(CH3SO3)3 ∙ 2H2O,23 montmorillonite K-10,24 MCM-41-SO3H,25 gallium triflate,[26] were reported. Introducing clean, versatile and eco-friendly processes have been under permanent attention
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