Abstract
Increased Risk of Depression in Non-Depressed HIV Infected Men with Sleep Disturbance: Prospective Findings from the Multicenter AIDS Cohort Study
Highlights
An estimated 36·7 million people worldwide are infected with HIV, and over 1·2 million persons in the US live with HIV [1]
Using data from N2500 men who have sex with men (MSM) enrolled in a longitudinal cohort study, this prospective investigation is the first to report that sleep disturbance contributes to greater risk of depression in HIV+ as compared to HIV- MSM
With 25 repeated visits of data collection and over 22,000 person-visit observations over 12 years, we provide evidence for the first time that sleep disturbance and HIV status significantly interact to predict depression in which the risk for depression was significantly greater in those with sleep disturbance who were HIV+ as compared to those who were HIV
Summary
An estimated 36·7 million people worldwide are infected with HIV, and over 1·2 million persons in the US live with HIV [1]. Major depression is more than three to four times more prevalent in HIV+ persons than in persons who are not. Among persons with HIV, the estimated lifetime prevalence of depressive disorders is as high as 22% to 45% [2,3]. Despite treatment with antiretroviral therapy (ART) [4], and control of HIV replication and reductions in HIV viral load [5], persons with HIV are at increased risk for depression. Understanding the factors associated with depression in persons living with HIV is needed to improve methods to identify the risk for depression, which could lead to targeted interventions for depression prevention
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