Abstract
Platelet aggregates were measured by the method of Wu and Hoak in patients with acute myocardial infarction, thrombotic stroke, chest infection, chronic peripheral arterial disease and bronchial carcinoma. All five groups had significantly higher levels of platelet aggregates and plasma fibrinogen than control patients and healthy volunteers. Platelet aggregate level was correlated with plasma fibrinogen (p<0.001). In patients receiving a 24 hour infusion of ancrod, platelet aggregates were reduced to normal levels. In control patients receiving a saline infusion, no change in platelet aggregates occurred. We suggest that platelet aggregates are increased in acute or chronic illnesses, whether vascular or not, and that fibrinogen or its degradation products may play a role in their formation.
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