Abstract
This study is to investigate the therapeutic effect of acupuncture treatment (ACT) on PSD through resting state functional connectivity analysis. The participants include seven PSD patients who have completed ACT trial and seven PSD patients who have completed the control trial. The resting-state functional connectivity patterns between the automated anatomical labeling brain regions were used to reveal the neuroimaging evidence for PSD with ACT. A two-factor mixed experimental design was adopted to investigate the interaction effect of acupuncture on PSD. The functional connectivity was increased in PSD patients after ACT but decreased in those without ACT after 3 weeks. The brain regions such as the right orbit middle frontal gyrus, paracentral lobule, right medial superior frontal gyrus, left angular gyrus, left anterior cingulate gyrus, and right supramarginal gyrus were related to sensorimotor and working memory. Significantly increased functional connectivity was found in PSD patients after ACT but not in those without ACT. ACT can enhance the functional connectivity in the brain. The results indicate that the sensorimotor and working memory of PSD patients is improved.
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