Abstract
OPINION article Front. Psychiatry, 15 November 2013Sec. Addictive Disorders https://doi.org/10.3389/fpsyt.2013.00148
Highlights
Reviewed by: Daniel Roche, University of California, Los Angeles, USA Emma Childs, The University of Chicago, USA
These models are of limited relevance to the experience of chronic psychosocial stressors and the resultant anxiety disorders seen in humans
Fourteen days of chronic subordinate colony housing (CSC) resulted in increased anxiety behavior, as measured by significantly less time spent in the lit box compared to single housing (SH) mice
Summary
Reviewed by: Daniel Roche, University of California, Los Angeles, USA Emma Childs, The University of Chicago, USA. There is a rationale and growing interest in developing medications with antistress and/or anxiolytic properties as putative treatments for AUDs. To this end, animal models that approximate or are relevant to human conditions of chronic stress and anxiety are relevant to test the effect of potential medications on alcohol-seeking behaviors. Previous studies with this model, using male mice only, reveal that CSC effects increased anxiety behavior as measured by elevated plus maze and light-dark box [6, 7].
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