Abstract
Dissolution rates of water-insoluble drugs such as digitoxin, 17-methyltestosterone, hydrocortisone acetate, and prednisolone acetate were markedly increased when dispersed in polyethylene glycol 6000. In addition, a supersaturation of each drug could be quickly attained when an excess amount of drug was studied. The increased dissolution rate was believed to be attributed to the molecular and/or the colloidal dispersion of the drug in the matrix of polyethylene glycol 6000.
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