Increased Concentrations of Dopamine in the Blood and the State of the Immune System in Practically Healthy Residents of the Northern Territories

Abstract

The numerous effects of dopamine are predetermined by the fact that it, being a chemical precursor of noradrenaline, is secreted in nervous tissue, in the adrenal medulla, kidneys, intestines, and APUD cells (Apudocytes). The purpose of the work is to study the effectiveness of immune reactions at elevated concentrations of dopamine in the blood of practically healthy residents of the northern territories. The results of an immunological examination of 1064 practically healthy people aged 25-55 years living in the Arkhangelsk and Murmansk regions, as well as in the Nenets Autonomous Okrug, the Komi Republic and the Svalbard archipelago (Barentsburg) were analyzed. It was found that elevated concentrations of dopamine in peripheral venous blood were more often recorded in Arctic residents; during the polar day, dopamine concentrations are higher than in winter. Increased concentrations of dopamine in the blood of Northerners are associated with a decrease in the level of activated T cells with the transferrin receptor and IL-2, T-helper cells, as well as with increased concentrations of IL-1β, TNF-α, cortisol and thyroxine. An increase in dopamine concentration may be a consequence of a cytokine reaction in the nervous tissue to inhibit excessive receptor activity of cells by increasing the concentration of IL-10. The formation of an excess of both central hormones secreted by the pituitary gland and peripheral hormones at the same time is probably due to an increase in the sensitivity threshold of the hypothalamus, which is associated with an increase in the flow of interoceptive impulses of afferent systems.