Abstract
The effect of essential fatty acid deficiency (EFA-D) on the plasma concentration of arginine-vasopressin (AVP) and the urinary AVP excretion was investigated. Weanling rats were fed a fat-free diet (FF-rats). Control rats received the same diet in which 6% by wt. of sucrose was replaced by arachis oil. After 4–6 weeks of feeding, urine and plasma were analysed for AVP, osmolality, sodium and potassium. When compared to control rats FF-rats had decreased urine volume (6.0±1.6 ml/24 hr versus 11.7±3.2 ml/24 hr), increased urine osmolality (2409±691 mOsm/kg versus 1260±434 mOsm/kg), increased urinary AVP excretion (5.52±1.62 ng/24 hr versus 2.19±1.20 ng/hr and increased plasma AVP (2.55±0.45 pg/ml versus 1.95±0.25 pg/ml. There was no difference between the groups in plasma osmolality. The triene/tetraene ration was 0.78+0.15 (n=12) in total kidney lipids of the FF-rats. The triene/tetraene ratio was positively correlated with urinary AVP excretion. It is concluded that FF-rats had elevated plasma AVP concentration and disturbed water balance, both of which probably were provoked by an increased transepidermal water loss.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
