Abstract
In two cases of idiopathic hypercholesterolemia, aged 6 and 12 years, it was found that in vivo incorporation of sodium acetate-1-14C into serum cholesterol was markedly increased, but that into squalene and lanosterol in serum was less than that in controls. In vitro incorporation of sodium acetate-3H or DL-mevalonic acid-2-14C into cholesterol was markedly increased in the liver homogenates from a patient with hypercholesterolemia, but it showed no difference between the patient and controls when skin, adipose tissue, bone marrow cells or leukocytes were used.
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