Abstract
Cocaine is believed to modify dopaminergic transmission by blocking reuptake thereby increasing the concentration in the synaptic cleft. The elevated dopamine concentrations at the synapse can affect both post- and presynaptic dopamine receptors. Since the former receptor mediates the functional effects of dopamine while the latter suppresses subsequent release of dopamine, it is unclear whether cocaine would enhance or diminish dopamine's influences. Results of the present study indicated that the primary functional result of cocaine is to enhance dopamine's postsynaptic effects.
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