Abstract
THE concentrations of tryptophan normally present in the mammalian brain are below the Michaelis constant (Km) of tryptophan hydroxylase1,2, suggesting that the rate of serotonin synthesis depends more on the concentration of brain tryptophan than on the amount of enzyme. We wish to report that various treatments which have been shown to increase brain serotonin synthesis also increase the concentration of tryptophan in brain. Conversely, p-chlorophenylalanine (PCPA), which inhibits serotonin synthesis3, decreases tryptophan in brain.
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