Abstract

The aim of this study was to examine the effect of intranasal administration of salmon calcitonin to a group of 24 postmenopausal women with severe ,established osteoporosis (t score < -2.5 SD) and more than one vertebral fracture. The patients were treated with 200 IU of nasal salmon calcitonin daily for 2 months with a subsequent pause of 2 months (3 cycles) and 500 mg calcium daily over a total of 12 months in an open randomized study. The patients were compared with an age matched control group of 18 women of a similar clinical status who were treated with calcium and vitamin D only.In the nasal calcitonin treatment group an increase in the trabecular axial bone density of 2.8% was achieved ,as well as an increase in the trabecular appendicular forearm) bone density of 1.6% ,together with a cortical bone density increase of 1.8% axial and 1% appendicular. Initially ,elevated values of urinary deoxgpgridinoline were found in 12 women in the nasal calcitonin treatment group; these levels returned to normal under salmon calcitonin nasal therapy and documented the inhibition of increased osteoclastic activity. Cyclic intermittent calcitonin nasal therapy led to a general increase in trabecular and cortical axial and appendicular bone density ,marked alleviation of the subjective sensation of pain ,and a reduction in the daily dose of accompanying nonsteroidal anti-inflammatory drugs by 50%.

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