Abstract
Slices from rat hypophysis, hypothalamus, brain cortex and cerebellum were incubated in vitro in the presence of 14C-uridine, and the incorporation of label into RNA was measured. Incorporation was linear with time and, in the hypophysis, inhibited significantly if the animals had been treated with 1.5 ml/kg of actinomycin D 90 min prior to killing. Rats were then given 20 mg/kg and 40 mg/kg of Δ 9-tetrahydrocannabinol ip, dissolved in propylene glycol, and killed 90 min later. Although these doses produced changes in behavior and hypothermia, they did not affect in vitro incorporation of 14C-uridine into RNA in the slices, nor did crude cannabis resin (75 mg/kg, po).
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