Abstract
Mineralized collagen fibrils (nHAC) are the main extracellular matrix composites of hard tissues, such as bone and teeth. nHAC formed in vivo contains trace of foreign ions, such as HPO42−, Cl−, Na+, and Sr2+. The role of Sr2+ on the composition and microstructure of nHAC is still unknown. In this study, we prepared Sr2+ incorporated nHAC via biomineralization of collagen fibrils. We evaluated the effects of Sr2+ on mineralization of collagen by using FTIR, XRD, SEM and TEM. The FTIR results revealed that HPO42−, CO32−, and OH− functional groups were all incorporated into nHAC. The FTIR, XRD, SEM and TEM results revealed that the incorporation of Sr2+ into nHAC did not influence the organization of apatite crystals and collagen fibrils. The inorganic phase was determined as apatite and the variation of lattice constants of apatite crystals gave evidence that the incorporation of Sr2+ produced distortions in the apatite crystal structure at PO43− sites. More CO32− ions were incorporated in the Sr-doped nHAC. Thus, the incorporation of Sr2+ into nHAC changed the composition and crystal structure of apatite crystals which grew on the surface of collagen fibrils.
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