Abstract
We describe a major development of the Shorten et al. (Shorten et al., 2007) model of skeletal muscle electrophysiology, biochemistry, and mechanics. The model was developed by incorporating equations for sarcolemmal transport of calcium ions, including L-type calcium channel, sodium-calcium exchange, calcium pump, and background calcium channel. The extended model also includes an addition to the equations for extracellular potassium ion movements to enable the exchange of potassium ions between bulk (plasma) concentration and the interstitial and tubular compartments to be modeled. In further research in an accompanying paper (Tasaki et al, 2019), we succeeded in reproducing muscle cramp, as well as its prevention and reversal, by investigating muscle contraction and cramp using this extended model in comparison with the original model.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
