Abstract
The complexity of next-generation drug modalities and delivery systems requires new and integrated analytical approaches. A progressive design of chromatographic instrumentation, stationary phases, flexible data systems, and integrated control are needed for chromatography to remain a leading relevant characterization tool. This paper provides an overview of some current and emerging physicochemical analytical challenges associated with these sophisticated drug systems and some of the technical advances needed in chromatographic systems to enable their design, development, and manufacture.
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