Abstract
Sporadic inclusion-body myositis (s-IBM) describes patients with chronic myositis whose biopsy specimens have, in addition to lymphocytic inflammation, abnormal muscle fibers containing characteristic filamentous inclusions in the cytoplasm and nuclei. Previously considered uncommon, s-IBM is now recognized as the most common muscle disease beginning over the age of 50 years. Its course is progressive, gradually leading to severe disability. Most disturbingly, there is no remarkably successful treatment available. Because clinical and pathologic diagnostic criteria of s-IBM are becoming better known, s-IBM is being identified more often by clinicians and pathologists. s-IBM was first described about 30 …
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